Sunday, March 31, 2013

Eiffel Tower evacuated after bomb threat

PARIS (AP) ? Police say the Eiffel Tower has been evacuated after an anonymous caller phoned in a bomb threat.

A Paris police official says nearly 1,400 people have been evacuated following a request from tower operators after the warning Saturday. Police then searched the monument with sniffer dogs for possible explosives, and set up a broad security perimeter.

French authorities have stepped up counterterrorism measures in recent weeks amid heightened concern about threats to France over its military campaign against al-Qaida-linked fighters in Mali which began more than two months ago.

The tower is occasionally evacuated because of such warnings ? at least once last year and twice in 2011. The 324-meter (1,063-foot) tower is one of the world's top tourist attractions, with millions of visitors a year.

Source: http://news.yahoo.com/eiffel-tower-evacuated-bomb-threat-204807606.html

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Former Nev. lawmaker arrested after freeway chase

LAS VEGAS (AP) ? Police chased a former lawmaker on a freeway between Las Vegas and Los Angeles and arrested him at gunpoint following a struggle, hours after he became the first person ever expelled from the Nevada Legislature.

Steven Brooks was jailed in California's San Bernardino County after being subdued with punches and a Taser. Police alleged he attacked a police dog with a wrench.

"It's hard to know where he was going, what he thought he was doing and why he would be involved in a high-speed chase," Brooks' attorney, Mitchell Posin, told The Associated Press on Friday. "I think he feels the world is against him. But I'm just piecing together bits of information."

Brooks' arrest Thursday near the California city of Victorville was his third since January, and came just hours after colleagues in the Legislature deemed the Democrat from North Las Vegas too dangerous and unpredictable to serve his elected term. Lawmakers wept Thursday as they cited concerns about their own safety and evidence collected about an increasingly bizarre series of public incidents.

Police allege that Brooks threatened a Democratic party Assembly leader before one arrest and threw punches and grabbed for the gun of a police officer in his second arrest about three weeks later. He also was hospitalized for five days for a mental evaluation following another police encounter that didn't result in an arrest.

He was sworn in and then banished from the Legislature building as a possible security risk days after arriving in a hooded sweatshirt and ducking into an office to avoid reporters.

He posed shirtless for a newspaper photograph to show injuries that he said he suffered during his first arrest, but that weren't apparent. He tried unsuccessfully to buy a rifle at a sporting goods store in Sparks. He bought body armor from a radio show host in Las Vegas. He lost his job as a Las Vegas city management analyst. And he reported his car stolen.

Assembly Majority Leader William Horne, D-Las Vegas, who called Brooks "potentially dangerous" and issued an order banning him from the Legislature building in Carson City, said Friday he was saddened by Brooks' arrest.

"I hope they get Steven the help he clearly needs before he or someone else is hurt or worse," Horne said.

During Thursday's arrest Brooks appeared to be punched by one uniformed officer before he was shackled by the wrists and ankles and taken away on an ambulance gurney. Police said the chase followed a call from a tow truck operator who argued with a motorist about the cost of fixing a flat tire on the freeway shoulder in Barstow.

"We just know the tow truck driver was uncomfortable enough to call us for assistance," California Highway Patrol Officer Don Spiker said. "He said the subject was acting strange."

The tow operator didn't immediately respond Friday to messages from The Associated Press.

Barstow police allege Brooks, 41, sped away with the tire still flat and tossed objects from the vehicle before a spike strip was deployed to disable the SUV and he tangled with uniformed officers and the police dog at the side of the freeway. The objects were not described, and police didn't respond to questions about whether Brooks was armed.

Witness Jennifer Simpson said she was alerted to the chase by police helicopters overhead and saw a man get out of a red four-door SUV after it veered to the side of the road near Victorville, about 180 miles southwest of Las Vegas.

Simpson, a mother of two who lives in an apartment near the interstate, said the man didn't follow officers' commands to turn around and put his hands in the air. He instead ran back to the SUV, chased by a police dog.

Simpson said the driver shut himself in the vehicle before several officers with guns drawn pulled him out. She said she saw at least one officer punch the man several times.

Simpson's husband videotaped four minutes of the struggle, in which uniformed officers wrestle the driver to the ground in front of the SUV and an officer in a tan uniform raises his arms three times in apparent punching motions. The driver cannot be seen on the ground.

Kris Reilly, city editor of The Daily Press in Victorville, said he arrived to see the motorist a few minutes later, struggling against wrist and ankle restraints as he was loaded on a gurney into an ambulance.

"He was yelling something to the effect that, 'These cops are going down!'" Reilly said. "He was yelling quite a bit."

Barstow Police Chief Albert Ramirez released a statement alleging that when the police dog was sent into the SUV, Brooks choked and hit the dog with a socket wrench. The dog, named Buck, was treated by a veterinarian head and leg cuts.

"Brooks continued to resist the officers and not comply with their orders," the Barstow police statement said. "A Taser was utilized on Brooks and after this, handcuffs were applied."

The police report does not describe any police officers being injured and doesn't address whether officers punched Brooks.

Telephone and email messages for Ramirez and other Barstow police supervisors weren't returned.

Brooks was examined at Barstow Community Hospital before he was taken to a San Bernardino County jail in Rancho Cucamonga, police said.

Jail records showed Brooks was being held on $100,000 bail on four felony charges including resisting a police officer with force, willful harm to a police service dog, felony evading arrest and throwing objects from a vehicle with intent to harm.

San Bernardino County sheriff's spokeswoman Cindy Bachman said Brooks was due for arraignment Tuesday in Barstow.

Brooks' expulsion from the state Assembly came by voice vote following a recommendation from a bipartisan panel that met largely behind closed doors. The seven panel members voted 6-1 for expulsion after considering a more than 900-page investigative report produced by a Las Vegas lawyer hired as a special counsel.

A coalition of Nevada media outlets is seeking to have the investigative report made public.

Brooks' first arrest was Jan. 19, after he was accused of making threats toward legislative colleagues including Assembly Democratic Speaker Marilyn Kirkpatrick. North Las Vegas police said Brooks had a gun and ammunition in his car when he was arrested. The state attorney general's office hasn't filed criminal charges in the case.

Brooks was sworn in at the Legislature on Feb. 4, but was arrested again Feb. 10 at his estranged wife's home in Las Vegas after police alleged he tried to punch and grabbed for the gun of an officer who responded to a domestic dispute. Brooks faces a court hearing in May in Las Vegas on one felony and three lesser charges.

___

Associated Press Writer Tami Abdollah in Los Angeles and researcher Rhonda Shafner in New York contributed to this report.

___

Find Ken Ritter on Twitter at http://twitter.com/krttr and Michelle Rindels at http://twitter.com/RindelsAP

Source: http://news.yahoo.com/former-nev-lawmaker-arrested-freeway-chase-080839188.html

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Health reform remains a mystery ? Bankrate, Inc.

Here's a fun exercise: Stop any average Jane or Joe on the street and ask them to list three salient features of health care reform. Then stand back and count the duhs.

What's the biggest obstacle now facing President Barack Obama's historic overhaul of American health insurance, what with early enrollment in the law's new state health exchanges just six months away?

Most people still don't get it?-- including those who will be able to afford health insurance for the first time because of it.

Survey finds a lack of understanding

A poll released last week by the Kaiser Family Foundation found that more than two-thirds (67 percent) of uninsured Americans age 65 and under, and 57 percent of the overall population, say they do not understand how the?Affordable Care Act will affect their lives. Among those from households with annual incomes of less than $40,000?who thus?would be most likely to?use the exchanges, 68 percent felt they had insufficient information to understand the impact health reform will have on their family.

In fact, what little clear sky the public was able to glimpse during the three-year political thunderstorm over health insurance reform seems to have?clouded over?with time. Today, 57 percent incorrectly believe the federal government will negotiate prices with doctors, half believe the law will help illegal immigrants buy health insurance, and 40 percent -- including 35 percent of seniors -- still expect "death panels" to spring forth?to make life-or-death decisions for Medicare beneficiaries.

Most have doubts

No wonder a majority of those polled were less than certain that health care reform would control costs, improve the quality of care and protect consumers. After all, if change is usually scary, change we don't understand is even more so.

Having written about most parts of the health reform law during the past three years, I'll be the first to admit it's a bear: incredibly complex, cleverly interwoven and, in my opinion, frequently brilliant. What's more, because most of its impact so far has been confined to hospitals, doctor's offices and insurance boardrooms, the public at large hasn't really had a chance to kick the tires.

But with tire-kicking time fast approaching as the state exchanges open this fall, it's clear from these poll numbers that federal and state health officials, and those of us who write about them, have plenty of work ahead to introduce Americans to their new, supposedly improved health care system.

Follow me on Twitter: @omnisaurus

Subscribe to Bankrate newsletters today!

Jay MacDonald is a Bankrate contributing editor and co-author of "Future Millionaires' Guidebook," an e-book by Bankrate editors and reporters.

Source: http://www.bankrate.com/financing/insurance/health-reform-remains-a-mystery/

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Saturday, March 30, 2013

NKorea says it is in 'a state of war' with SKorea

A visitor looks at North Korean territory at the unification observation post near the border village of Panmunjom, that has separated the two Koreas since the Korean War, in Paju, north of Seoul, South Korea, Saturday, March 30, 2013. North Korea issued its latest belligerent threat Saturday, saying it has entered "a state of war" with South Korea a day after its young leader threatened the United States because two American B-2 bombers flew a training mission in South Korea. (AP Photo/Lee Jin-man)

A visitor looks at North Korean territory at the unification observation post near the border village of Panmunjom, that has separated the two Koreas since the Korean War, in Paju, north of Seoul, South Korea, Saturday, March 30, 2013. North Korea issued its latest belligerent threat Saturday, saying it has entered "a state of war" with South Korea a day after its young leader threatened the United States because two American B-2 bombers flew a training mission in South Korea. (AP Photo/Lee Jin-man)

Visitors look at a giant relief map of Korean Peninsular at the unification observation post near the border village of Panmunjom, that has separated the two Koreas since the Korean War, in Paju, north of Seoul, South Korea, Saturday, March 30, 2013. North Korea issued its latest belligerent threat Saturday, saying it has entered "a state of war" with South Korea a day after its young leader threatened the United States because two American B-2 bombers flew a training mission in South Korea. (AP Photo/Lee Jin-man)

Visitors use binoculars to watch North Korean territory at the unification observation post near the border village of Panmunjom, that has separated the two Koreas since the Korean War, in Paju, north of Seoul, South Korea, Saturday, March 30, 2013. North Korea issued its latest belligerent threat Saturday, saying it has entered "a state of war" with South Korea a day after its young leader threatened the United States because two American B-2 bombers flew a training mission in South Korea. (AP Photo/Lee Jin-man)

Visitors take pictures North Korean territory at the unification observation post near the border village of Panmunjom, that has separated the two Koreas since the Korean War, in Paju, north of Seoul, South Korea, Saturday, March 30, 2013. North Korea issued its latest belligerent threat Saturday, saying it has entered "a state of war" with South Korea a day after its young leader threatened the United States because two American B-2 bombers flew a training mission in South Korea. (AP Photo/Lee Jin-man)

A man uses binocular to watch North Korean territory at the unification observation post near the border village of Panmunjom, that has separated the two Koreas since the Korean War, in Paju, north of Seoul, South Korea, Saturday, March 30, 2013. North Korea issued its latest belligerent threat Saturday, saying it has entered "a state of war" with South Korea a day after its young leader threatened the United States because two American B-2 bombers flew a training mission in South Korea. (AP Photo/Lee Jin-man)

(AP) ? North Korea warned Seoul on Saturday that the Korean Peninsula was entering "a state of war" and threatened to shut down a factory complex that's the last major symbol of inter-Korean cooperation.

Analysts say a full-scale conflict is extremely unlikely, noting that the Korean Peninsula has remained in a technical state of war for 60 years. But the North's continued threats toward Seoul and Washington, including a vow to launch a nuclear strike, have raised worries that a misjudgment in how to address the warnings could lead to a clash.

The Kaesong industrial park, which is run with North Korean labor and South Korean know-how, has been operating normally, despite Pyongyang shutting down a communications channel typically used to coordinate travel by South Korean workers to and from the park just across the border in North Korea. The rivals are now coordinating the travel indirectly, through an office at Kaesong that has outside lines to South Korea.

But an identified spokesman for the North's office controlling Kaesong said Saturday that it would close the factory park if South Korea continued to undermine its dignity. Pyongyang expressed anger over media reports that suggested the factory remained open because it was a source of hard currency for the impoverished North.

Dozens of South Korean firms run factories in the border town of Kaesong. Using North Korea's cheap, efficient labor, the Kaesong complex produced $470 million worth of goods in 2012.

North Korea has previously made such threats about Kaesong without acting on them, and recent weeks have seen a torrent of bellicose rhetoric from Pyongyang. North Korea is angry about annual South Korea-U.S. military drills and new U.N. sanctions over its nuclear test last month.

North Korea's threats are seen as efforts to provoke the new government in Seoul, led by President Park Geun-hye, to change its policies toward Pyongyang, and to win diplomatic talks with Washington that could get it more aid. North Korea's moves are also seen as ways to build domestic unity as young leader Kim Jong Un strengthens his military credentials.

On Thursday, U.S. military officials revealed that two B-2 stealth bombers dropped dummy munitions on front lines as part of drills with South Korean troops. Hours later, Kim ordered his generals to put rockets on standby and threatened to strike American targets if provoked.

North Korea said in a statement Saturday that it would deal with South Korea according to "wartime regulations" and would retaliate against any provocations by the United States and South Korea without notice.

"Now that the revolutionary armed forces of the DPRK have entered into an actual military action, the inter-Korean relations have naturally entered the state of war," said the statement, which was carried by Pyongyang's official Korean Central News Agency, referring to the North's official name, the Democratic People's Republic of Korea.

Provocations "will not be limited to a local war, but develop into an all-out war, a nuclear war," the statement said.

South Korea's military remains mindful of the possibility that North Korean drills could lead to an actual provocation, Defense Ministry spokesman Kim Min-seok said.

"The series of North Korean threats ? announcing all-out war, scrapping the cease-fire agreement and the non-aggression agreement between the South and the North, cutting the military hotline, entering into combat posture No. 1 and entering a 'state of war' ? are unacceptable and harm the peace and stability of the Korean Peninsula," Kim said.

"We are maintaining full military readiness in order to protect our people's lives and security," he told reporters Saturday.

Naval skirmishes in the disputed waters off the Korean coast have led to bloody battles several times over the years.

However, on the streets of Seoul, South Koreans said they were not worried about an attack from North Korea.

"From other countries' point of view, it may seem like an extremely urgent situation," said Kang Tae-hwan, a private tutor. "But South Koreans don't seem to be that nervous because we've heard these threats from the North before."

___

Follow Sam Kim at www.twitter.com/samkim_ap.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-30-AS-Koreas-Tension/id-f914cb38ceee4d54977548c286b64654

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Exclusive: Indonesia's CT Corp proposes all-cash deal for Bakrie's media unit

By Janeman Latul and Randy Fabi

TANJUNG BENOA, Indonesia (Reuters) - Indonesia's fifth-richest man has proposed to buy a controlling stake in PT Visi Media Asia, valued at up to $1.8 billion, in an all-cash deal that would give him the lion's share of the TV advertising market in Southeast Asia's biggest economy.

Chairul Tanjung, the billionaire founder and chairman of CT Corp, a conglomerate with banking and media interests, told Reuters that his company wanted to buy the stake in the media unit of Indonesia's powerful Bakrie family without any partners.

The purchase would add Visi Media's two television stations to the two that CT Corp already owns, giving Tanjung's company a market share of more than 40 percent by TV ad revenue. Media companies are eyeing growth in the overall advertising market - worth $1.7 billion in 2011, according to the latest government data - on the back of Indonesia's rapid economic expansion.

"We are one of the preferred bidders. Our proposal is we want to buy it all ... my pocket is still deep," the 51-year-old Tanjung said in his hotel room on the resort island of Bali, shortly after meeting with the president and cabinet ministers in his role as head of the president's economic advisory body.

"(It is) only us that can pay cash one hundred percent ... but the deal is not done yet."

Tanjung said CT Corp would take out a new loan to buy the Visi Media stake. He declined to say how much the company would borrow for the deal.

Indonesia's politically influential Bakrie family has been in talks to sell around a 51 percent stake in Visi Media to help finance a plan to buy back coal assets from London-listed Bumi Plc , sources with direct knowledge have told Reuters.

The Bakries had originally been looking for a valuation of $1.2 billion to $2 billion for the unit, but the sources said it would be worth up to $1.8 billion. The talks have been going on for the past three months with local bidders including CT Corp and MNC Group, the sources said.

Currently, MNC group is the TV sector leader with a 38 percent share by ad revenue. CT Corp's Trans Media Group has a 24.8 percent share and the Sariaatmadja family's Elang Mahkota media group has 23.8 percent, government data shows.

Tanjung's comments marked the first time any bidder has publicly announced that it was offering to buy the company.

MNC was not immediately available for comment.

Shares of Visi, which has a market value of around $800 million, did not trade on Friday because of a public holiday.

'BUILD A CITY'

Tanjung, who trained as a dentist before becoming a businessman, has a net worth of around $3.4 billion, according to Forbes.

He started his company in 1987, building it from a maker of footwear and roof tiles to a conglomerate with interests from financial firms like PT Bank Mega Tbk to the CT Agro palm oil company.

Targeting strong growth in the local consumer industry, CT Corp has bought a 60 percent stake in the Indonesian supermarket operations of European retailer Carrefour for $673 million.

CT Corp also plans to build a $3 billion theme park on Indonesia's Java island and make it one of the biggest theme parks in Southeast Asia when it opens in 2016, Tanjung said.

He said the land for the park would be around 200 hectares and that construction would start by the end of this year.

The group currently operates two theme parks and has plans to add another 20 theme parks across Indonesia over the next few years.

"We will build a city, not only a theme park, as I want to make many Indonesians feel happy," Tanjung said.

(Editing by Jonathan Thatcher and Chris Gallagher)

Source: http://news.yahoo.com/exclusive-indonesias-ct-corp-proposes-cash-deal-bakries-041447140--finance.html

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Tonawanda Coke Corporation Pollution Trial Heads To Jury Deliberation In New York


By Neale Gulley
BUFFALO, N.Y., March 27 (Reuters) - Jury deliberations were set to begin on Thursday in the federal trial of Tonawanda Coke Corp, which has been charged with fouling the air for years, and whose environmental manager is accused of hiding plant deficiencies from U.S. regulators.
Chief U.S. District Judge William Skretny issued instructions to the jury for several hours on Wednesday and told the panel to begin deliberations on Thursday morning.
The western New York company faces a 19-count indictment that lists numerous violations of the federal Clean Air Act, the Resource Conservation and Recovery Act and obstruction of justice for an alleged cover up of emissions prior to a 2009 investigation by the Environmental Protection Agency. If found guilty, the company faces fines for each count.
The company, which has operated for 30 years in the Buffalo suburb of Tonawanda, produces a coal-based additive called coke that is used to make steel.
Prosecutors said the company's air permit application did not mention a pressure relief valve emitting noxious coke oven gas. Other violations of federal law, they said, include the failure to install required emission control devices called baffles.
"Time and again, the defendants chose to deceive, not comply, all in an attempt to put profit above all else," Assistant U.S. Attorney Aaron Mango said in closing arguments on Tuesday.
"Money drove this business into deception," he added.
The cost of installing baffles was estimated at $125,000, prosecutors said. However, defense attorneys said that sum would not have made compliance cost-prohibitive had the plant been aware that baffles were an issue.
"This is not a substantial cost that reasonably and rationally would drive criminal acts," defense attorney Gregory Linsin said during his closing argument.
Instead, Linsin took aim at the New York State Department of Environmental Conservation, which he said had granted the plant an exception to the baffles in one area of the plant. While the agency knew the devices were not installed elsewhere as required, he said, it failed to enforce the issue.
Of the relief valve, Linsin said the apparatus was in a "clear and obvious location" and that DEC inspectors were well aware of it for decades.
Linsin said DEC officials failed to take action even though they had granted exceptions and knew of other violations.
"The conduct that is the subject of this indictment was known, at least tacitly if not explicitly, to the DEC for years," he said.
Linsin accused DEC officials of entrapment - the company's primary defense - saying they led plant managers to believe the facility was in compliance. The state officials, he said, allowed problems to linger for years before EPA investigators conducted their own review in 2009.
Linsin said the plant passed inspections for a long time and worked hard to comply with state and federal regulations.
"The only thing that changed, ladies and gentlemen, in 2009, was a new sheriff came to Tonawanda Coke in the form of the EPA," he said.
The surprise weeklong investigation by the state and EPA led to the indictment.
Previously, nearby residents had formed a coalition because they were concerned about high cancer rates in the area.
A state Department of Health study released this year found "statistically significant elevations" of cancer and birth defects among Tonawanda residents. But health officials say the study does not prove local industry caused the health problems.
Mark Kamholz, the environmental manager named in the indictment, could face prison if convicted of the lone obstruction charge against him.
Prosecutors accuse Kamholz of using "his position of control to manipulate and deceive investigators from identifying areas of non-compliance." (Editing by Barbara Goldberg, Lisa Von Ahn and Ellen Wulfhorst)

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/03/28/tonawanda-coke-corporation-pollution_n_2966819.html

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Friday, March 29, 2013

South Africa leader Zuma: We 'must not panic' over health of Nelson Mandela

The former South African president is responding to treatment for a recurring lung infection, officials say. This marks the third time in four months the 94-year-old has been hospitalized. NBC's Keir Simmons reports.

By Alastair Jamieson, Staff writer, NBC News

Former South Africa leader Nelson Mandela was in ?good spirits? Friday, officials said, as he spent a second day in hospital where he is being treated for a recurring lung infection.

?The doctors report that he is making steady progress,? said a statement from the country?s presidency, adding that the 94-year-old had ?enjoyed a full breakfast.?

Earlier, South Africa?s president, Jacob Zuma, sought to reassure his country over Mandela?s health,?saying in a BBC interview that people "must not panic."

However, he appeared to agree with the suggestion that South Africa should prepare for Mandela?s eventual death.

?Is this a time for us to be aware of what is inevitable?? asked the BBC's Lerato Mbele. ?Well, I would imagine so,? replied Zuma.

Mandela, 94, was taken to a hospital just before midnight local time (6 p.m. ET) on Wednesday ? his third hospital visit since December.

He has a history of lung problems dating back to his days as a political prisoner in the notorious Robben Island jail under the apartheid regime, where inmates worked in an open quarry. He was diagnosed with tuberculosis in 1988 after being moved to Pollsmoor Prison.

Mandela spent 18 days in hospital in December, undergoing surgery for gallstones.

Earlier, President Barack Obama sent his best wishes to the former leader.

"He is as strong physically as he's been in character and in leadership over so many decades, and hopefully he will ... come out of this latest challenge," Obama told reporters at the White House Thursday.

"When you think of a single individual that embodies the kind of leadership qualities that I think we all aspire to, the first name that comes up is Nelson Mandela. And so we wish him all the very best," Obama said.

NBC News? Stacey Klein contributed to this report.

Related:

Secrecy over Mandela's health fuels concern for South Africa icon

'Who is my Mandela?' South Africans consider icon's place in a changing world

?

This story was originally published on

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Common gene variants explain 42 percent of antidepressant response

Friday, March 29, 2013

Antidepressants are commonly prescribed for the treatment of depression, but many individuals do not experience symptom relief from treatment. The National Institute of Mental Health's STAR*D study, the largest and longest study ever conducted to evaluate depression treatment, found that only approximately one-third of patients responded within their initial medication trial and approximately one-third of patients did not have an adequate clinical response after being treated with several different medications. Thus, identifying predictors of antidepressant response could help to guide the treatment of this disorder.

A new study published in Biological Psychiatry now shares progress in identifying genomic predictors of antidepressant response.

Many previous studies have searched for genetic markers that may predict antidepressant response, but have done so despite not knowing the contribution of genetic factors. Dr. Katherine Tansey of Institute of Psychiatry at King's College London and colleagues resolved to answer that question.

"Our study quantified, for the first time, how much is response to antidepressant medication influenced by an individual's genetic make-up," said Tansey.

To perform this work, the researchers estimated the magnitude of the influence of common genetic variants on antidepressant response using a sample of 2,799 antidepressant-treated subjects with major depressive disorder and genome-wide genotyping data.

They found that genetic variants explain 42% of individual differences, and therefore, significantly influence antidepressant response.

"While we know that there are no genetic markers with strong effect, this means that there are many genetic markers involved. While each specific genetic marker may have a small effect, they may add up to make a meaningful prediction," Tansey added.

"We have a very long way to go to identify genetic markers that can usefully guide the treatment of depression. There are two critical challenges to this process," said Dr. John Krystal, Editor of Biological Psychiatry. "First, we need to have genomic markers that strongly predict response or non-response to available treatments. Second, markers for non-response to available treatments also need to predict response to an alternative treatment. Both of these conditions need to be present for markers of non-response to guide personalized treatments of depression."

"Although the Tansey et al. study represents progress, it is clear that we face enormous challenges with regards to both objectives," he added. "For example, it does not yet appear that having a less favorable genomic profile is a sufficiently strong negative predictor of response to justify withholding antidepressant treatment. Similarly, there is lack of clarity as to how to optimally treat patients who might have less favorable genomic profile."

Additional research is certainly required, but scientists hope that one day, results such as these can lead to personalized treatment for depression.

###

Elsevier: http://www.elsevier.com

Thanks to Elsevier for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127522/Common_gene_variants_explain____percent_of_antidepressant_response

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Ways On How To Efficiently Improve Your House

There are a number of reasons why people want to spend money on home projects. These projects can be anything from tiny details that take a few hours to complete to major structural changes that involve weeks of labor. Whether hiring a pro or doing it on your own, there are many important factors to take into consideration before beginning any home improvement project. The article below is brimming with tips and tricks to help you get the most out of your home improvement efforts.

These are quite common in older houses and can evolve quickly into serious issues. Tackling them when they're little is simple and easy. Waiting until they're big problems can be costly and costly. A bit of bleach can work really well on little mold issues. You can sand away small patches of rust.

Use fans when you are renovating in your home during the summer. Ceiling fans can be particularly great for increased circulation and cooling.

Use baby food jars to add organization to your work area. You should screw or glue to attach these jars underneath a wall shelf. You can put small items like nails and screws. This is a great way to use your wall shelf and recycle the jars you might not use otherwise.

If you're looking to replace your home's siding, you must remember insulation. It will add to the resale value of your house as well as lower energy costs. You can put that extra money in hand.

Homes that are well maintained tend to sell for a higher price than homes that haven't. This type of earning back your investment.

If your roof leaks, you should start by checking near the chimney, wall step flashing, in any low spots, and near your wall step flashing. Gutters that are damaged often cause a roof to leak because water goes directly down the outside of the home.

Green home improvements are always great to do in your home. It's a fantastic way to add some value as well as to be environmentally friendly. Installing an air conditioning or furnace that is energy efficient will make your home more comfortable, saves energy costs and helps keep the earth clean.

If you are working on your gas lines or anything connected to them, take the time to be sure the gas has been turned off completely. Just because you're not smoking in your home doesn't mean you won't end up creating a spark. Also, even if you think you haven't done any damage, so be careful.

Remember that safety precautions when it comes to home improvement jobs. There is some danger in any home improvement project you do, so make sure to read the instructions on power tools and ask for help from store associates if you need it. You can find many online tutorial which can help.

You can complete home improvement projects on your own. You might be able to paint, simple plumbing repairs, and certain drywall jobs on your own. You can keep some money by simply doing the repairs yourself.

Major home improvements generally need permits and approval before the work is commenced.If you aren't aware of local regulations or you don't undertake structural property changes, then you need a professional so that you can prevent serious mistakes that can cost you a lot.

Be mindful of which product you select to tackle stubborn clogs. Some drain cleaners are very harsh and dangerous. Don't used drain cleaners that are crystallized because they will stick to the inside of the pipes and damage them. Be sure to use drain cleaning products intended for use with the type of septic tank you have.

The leveled line creates a useful reference point for measuring when putting in your cabinets. The benchmark line should start the floor's highest pot.

If your bedroom set is tired and worn, you can try your hand in building your own. While this requires a great deal of work, you can create beautiful furniture styled directly to your own personal taste.

You can save a lot on homeowner's insurance by installing smoke alarms in your home and checking them regularly. This effect is greater with older homes because the insurance companies know that more recent homes are usually built using materials that are more fire-resistant. Smoke alarms are essential safety equipment; they could save money and your life.

Always check the legitimacy of any company you plan to hire is a legitimate one. Try to get with a company that has a solid reputation.

Don't buy furniture that has busy patterns.You can experiment with patterns to your heart's content with pillows and throws without making too much of a unique effect.

Are you discovering that your summer heating bill? It's easy - most people have the ability to do yourself. In the end, tinting your windows will help lower your overall cooling bill.

Be certain to seal your grout once the tile has been laid. If it is not sealed, you may find that moisture seeps inside the grout, and mildew and mold can result. By sealing the grout, you will save time when cleaning tiles and prevent unnecessary costs for mildew issues.

Updating your home can be an expensive and lengthy process. However, if you know what you're doing, your expenditures will be far less. Make use of this article's great advice so that you can avoid making common mistakes and ensure your home improvement project turns out great.
 Ways On How To Efficiently Improve Your House

Source: http://yarwoodrealestate.com/ways-on-how-to-efficiently-improve-your-house/

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This Bizarre Media Streamer Is Your Deal of the Day

The Boxee Box came out in November 2010, which is eons ago in gadget time. Since then, there has been a new Apple TV, two new flagship Rokus, and even a new Boxee. The king of the streamer world is now the $100 Roku 3. Still—this absurdly shaped open-source streamer has quite the following, and that's because it's the last major set top box to embrace a maximalist, open philosophy: wanna plug in a hard drive and play some Xvid files? Sure! Channels for MLB.tv, or Netflix or Youtube? Got 'em. Hey, want to catch some over-the-air television? You can do that with a $50 dongle. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Fnhr1oFYEKA/this-bizarre-media-streamer-is-your-deal-of-the-day

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Newtown school gunman had large weapons cache: court papers

By Mary Ellen Clark

MERIDEN, Connecticut (Reuters) - The gunman who attacked a Newtown, Connecticut, elementary school in December had several additional firearms not used in the attack and hundreds of rounds of ammunition, according to court papers released on Thursday.

Connecticut officials released dozens of pages of court documents on their investigation into Adam Lanza, a 20-year old man who killed his mother, 20 first grade school children and six staff members before turning a gun on himself in the second deadliest school shooting on record in the United States.

A 90-day sealing order expired on the search warrants that were served on Lanza's home and property. The search also turned up certificates from the National Rifle Association gun-lobby group in the names of both Adam Lanza and his mother, Nancy Lanza.

The assault last December 14 at the Sandy Hook Elementary School prompted President Barack Obama to call it the worst day of his presidency and reignited a debate on gun violence in the United States. In response to the attack, the NRA called for armed guards to patrol every public school in the country.

The documents were released on the same day that a group of Newtown residents plan a protest at the National Shooting Sports Foundation, less than 3 miles from the school over the NRA's opposition to new gun control laws. Newtown residents were enraged after receiving a slew of robo-calls on behalf of the NRA bashing anti-gun laws.

(Additional reporting by Barbara Goldberg, writing by Scott Malone; Editing by Paul Thomasch and Grant McCool)

Source: http://news.yahoo.com/documents-sandy-hook-gunman-set-release-thursday-125123242.html

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Watch These Classic Movie Trailers Re-Purposed for Vine

Trailer-editing professionals TOKYO experimented with Vine recently by re-editing a handful of trailers into six-second, near seizure-inducing cinematic bursts inspired by The Wolverine Vine trailer. You've never seen Aliens like this. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/N9jJYLdicb0/watch-these-classic-trailers-re+purposed-for-vine

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Rev. Emily C. Heath: Maundy Thursday and the Love Mandate

The most common question I get asked during Holy Week is about this night, the Thursday before Easter. People get Palm Sunday, and Good Friday, and Easter, but tonight, Maundy Thursday, is unclear. And the one thing people want to know the most, is this: What does "Maundy" mean?

It's a good question. Who uses the term "maundy" in their daily life? For those on the outside of the church, and even for those of us inside, it might just sound like a church service where we know we should want to go to it, but we have no idea why.

But before I talk about what the word means, I want to go back to that story we read from the Gospel. In it Jesus has gone to Jerusalem for the Passover. He's gathered his 12 disciples there at the table. And he knows what is going to happen. He knows that by the end of the night one of them will betray him to the authorities. One will deny him three times. And all of them will leave him alone in his hour of greatest pain.

And yet, there he is. Breaking the bread and pouring the cup. Eating with them. Blessing them. Getting down on his knees and washing their feet, showing them his love and grace and compassion, in a time when we might have better understood his wrath or anger.

In a world where we are often surrounded by messages of retaliation, or vengeance, or an eye for an eye cries for justice, it's a different message. Jesus had done nothing wrong. He'd lived a life of nonviolence, he'd healed the sick, raised the dead and freed the captives. He'd brought hope and life to those who needed it the most.

And in the end, he knew that he was not about to be thanked. He was about to be killed. Because in the end, the goodness and the kindness and the compassion he had brought were more of a threat to the Roman authorities, and clergy of his day, than any weapon or any army. He so radically upset the status quo that they decided their only choice was to kill him.

The night before, he wasn't running away. He wasn't preparing for a battle. He wasn't plotting his revenge. Instead, he was with the ones he loved most. The ones who loved him, but who weren't perfect. The ones who knew who he was, and what he had done, and who would be the witnesses to his life after he was gone.

And that's where that word "maundy" comes in. Because what do you do if you're Jesus? What do you do if you know you are not going to be around much longer, and you have to tell the people you love the most, the ones who followed you, the ones who sometimes make big mistakes, how to keep moving in the right direction after you're gone?

The word "maundy" comes from a Latin word: mandatum. And mandatum means "mandate" or a "commandment". And when we talk about "Maundy Thursday" we're talking about "mandate Thursday." We're talking about the night that Christ told his disciples exactly what he expected of them.

And if you read a book or watch a movie about almost anyone else, you might think the lead character right about now would be saying something like "avenge my death" or "make sure there's payback" or "don't let them get away with this ... strike back."

But this isn't any other story. This is a story that turns everything on its head. The mandate, the mandatory thing Jesus tells us to do in this passage is this:

"I give you a new commandment, that you love one another. Just as I have loved you, you also should love one another. By this everyone will know that you are my disciples, if you have love for one another."

It probably wouldn't do well at the box office. It wouldn't get Nielsen ratings. The story wouldn't soar to the top of the New York Times best-sellers list today. But it's a story that transcends all of those things. Because it's the beginning of a story about what happens when the world does its worst through violence and hatred and fear, and yet love wins anyway. It's a story of love that was rejected and buried, and yet was still too strong to stay in the ground.

It's not my job to rename Christian holy days. But if it were, I might change the name of Maundy Thursday. I might change it from this word that none of us really know anymore to something we would all understand. Something like "Love One Another Thursday" or "The Last Thing Christ Really Wanted Us to Know Thursday."

Because this is a message we Christians all need to hear. We don't need to hide it behind fancy terms. We don't need to just check it off as another night in holy week. We need to hear that this is how Christ said other people would know us: by how we love one another.

Maybe it would help us remember. Maybe it would help us remember not just what this night is about, but maybe it would help us remember what it means to be Christians. And maybe if we always had that reminder, if we always had that commandment to love in the front of our head, Christ's dream for us would come true.

Maybe we wouldn't be known as Christ's disciples by the fact we put a Christian fish sticker on our car. Or wore a cross around our necks. Maybe we wouldn't be know by what we said about what we believed. Maybe we wouldn't be known by our what we voted for, or against. Maybe we wouldn't be known by the anger some Christians express on the evening news, or the mean-spiritedness others show in their day-to-day lives. Maybe instead we would just be known by the one thing Christ wanted us to be known for: by how we love.

In a few minutes we will be celebrating Communion together, and you'll hear me repeat the words of institution, the phrases we are told Christ used as he broke bread and gave it to his disciples for the first time, on this same night many years ago. I'll say to you that "on the night Christ was betrayed he took bread, and blessed it, and gave it to his disciples."

You hear that all the time here, and if you are like me, you are uplifted by it.

But what if you heard this just as often too? "On the night Christ was betrayed he turned to his disciples and said, 'I give you a new commandment, that you love one another. Just as I have loved you, you also should love one another. By this everyone will know that you are my disciples, if you have love for one another.'"

We don't say that often in service. Not in so many words. But I think we try to say it in the breaking of the bread and the sharing of the cup. It's no coincidence Christ said these things on the night of his last supper, but we sometimes forget the say the words.

This year, let's not forget. Between this Maundy Thursday and the one next year, let's not forget what the mandate is. It's so simple, and yet it demands our whole lives and our whole attentions. But here in the church, we can give Christ nothing less. Tonight, as we eat this bread and drink this cup, as simple as it seems on the outside, know that we are choosing no less than to feast upon Christ's love for us, and to bring that feast out to others. If every Christian would do that, no one would ever have to ask us who we follow. By our love, they would already know. Amen.

?

Follow Rev. Emily C. Heath on Twitter: www.twitter.com/calledoutrev

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Source: http://www.huffingtonpost.com/rev-emily-c-heath/maundy-thursday-and-the-love-mandate_b_2941615.html

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TapTapPass Quickly Enables Your iPhone's Passcode from Anywhere

TapTapPass Quickly Enables Your iPhone's Passcode from AnywhereiOS (Jailbroken): If you want to enable the passcode on your iPhone you usually need to jump into the settings, hit the toggle, and enter your passcode. It's a bit tedious, but if you want to speed up the process TapTapPass makes it possible to enable your passcode from pretty much anywhere.

TapTapPass works with Activator so you can set up a tap or gesture to instantly enable your passcode. When you perform the activator function, the screen locks with the passcode enabled. After you unlock it once, the passcode is disabled again. If you're the type to only need a passcode occasionally, this is a great way to get the benefits of a passcode without the trouble of having it on all the time. Of course, you can always automate the process as well.

TapTapPass | Modmyi via iDownloadBlog

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/1FD4d50CbbE/taptappass-quickly-enables-your-iphones-passcode-from-anywhere

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Thursday, March 28, 2013

S&P 500 moves above its record high, keeps going

Specialist Mario Picone, left, works with traders at his post on the floor of the New York Stock Exchange Monday, March 25, 2013. U.S. stock markets are opening higher after Cyprus clinched a last-minute bailout that saved it from bankruptcy. (AP Photo/Richard Drew)

Specialist Mario Picone, left, works with traders at his post on the floor of the New York Stock Exchange Monday, March 25, 2013. U.S. stock markets are opening higher after Cyprus clinched a last-minute bailout that saved it from bankruptcy. (AP Photo/Richard Drew)

NEW YORK (AP) ? The Standard & Poor's 500 crossed into record territory Thursday, beating a previous all-time high set in pre-financial crisis days.

The S&P 500, a stock index that investors use to gauge how the market is performing, edged above the record of 1,565 it set on Oct. 9, 2007. Around 11 a.m. EDT, it was trading at 1,567, up four points on the day.

The record comes against a backdrop of big stock market gains but continued uncertainty about the economy. Earlier this month, the Dow Jones industrial average, another popular barometer of the stock market, beat its own 2007 record and has continued to rise.

Even as the indexes touch new milestones, investors wonder how long the gains can last given Europe's lingering debt problems and the plodding growth of the U.S. economy. They're also concerned that the gains are being artificially fueled by the Federal Reserve's easy money policy.

Like the Dow record before it, the S&P record reminded investors of a headier time. October 2007 was pre-financial crisis, pre-bailouts, pre-Great Recession. Bear Stearns still existed. So did Lehman Brothers, Wachovia and Washington Mutual. The jobless rate was 4.7 percent, well within the bounds of what most economists consider full employment.

But by March 2009, long after the subprime mortgage market had been revealed as an unsustainable bubble and rumors were buzzing that the government might nationalize U.S. banks, the S&P had cratered from its lofty heights. It fell to its Great Recession low, 676.53, on March 9, 2009 ? down 57 percent from its October 2007 pinnacle. It has more than doubled since reaching that bottom.

Howard Silverblatt, senior index analyst at S&P Dow Jones Indices, said that the S&P 500's return to its old record marked "an important step" for investors. But he cautioned that there are no guarantees for future performance.

"Markets are volatile," he wrote in a note to clients Thursday morning, "and if you are a long-term investor you should expect declines."

On Thursday, news about the U.S. economy and the European debt crisis was far from decisive. For every sign that things were improving, another said it wasn't.

The U.S. economy grew faster than first estimated in the fourth quarter, the government reported. But the growth, an annual rate of 0.4 percent, was still anemic. The number of Americans seeking unemployment benefits jumped for the second straight week. On a longer time frame, though, jobless claims have been declining since November.

Investors are also uncertain what to make of the continuing debt crisis in Europe, including the bailout of the Mediterranean island country of Cyprus. Banks there reopened Thursday for the first time in nearly two weeks.

The banks had been closed because the government was negotiating emergency loans from other European countries, and there were concerns that there would be a run on the banks. Across Cyprus on Thursday, customers stood in long but orderly lines for hours ahead of the bank openings, and guards from private security firms reinforced police outside some ATMs and banks in the capital, Nicosia.

Some investors had predicted that a bailout plan for Cyprus would send the markets up because it would calm concerns that the country's banking system might collapse. But the markets have been mixed this week. Some investors said the Cyprus bailout served as a reminder that Europe's debt crisis lingers.

Like other major market indicators, the S&P darted between small gains and losses when trading first opened. In late morning trading the Dow Jones industrial average rose 45 points, or 0.3 percent, to 14,571. The Nasdaq composite rose four points, 0.1 percent, to 3,260.

Among stocks making big moves:

?Research In Motion, the maker of BlackBerry phones, rose after surprising analysts with a profitable quarter and better-than-expected sales of its touch-screen BlackBerry 10s. The company hopes to take back some of the market share it has lost to Apple's iPhone and other competitors. The stock rose 59 cents, about 4 percent, to $15.16.

?Repros Therapeutics, a drug developer, shot higher on news that its potential treatment for low testosterone moved closer to regulatory approval. The stock rose $6.27, or 69 percent, to $15.40.

?Signet Jewelers, which runs Kay and Jared stores, and Mosaic, the fertilizer maker, were both up after reporting higher quarterly profits and revenue. Signet rose more than 7 percent, $4.74, to $68.01. Mosaic was up more than 1 percent, rising 83 cents to $59.51.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-28-Wall%20Street/id-8335239cd8484ad191db998997319967

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Would Amanda Knox have to go back to Italy if she's tried twice?

By Terry Baynes

NEW YORK (Reuters) - The possibility that American Amanda Knox could be convicted of murder and extradited to Italy for punishment could force U.S. courts to enter legal territory that is largely uncharted, legal experts said.

Italy's top court on Tuesday ordered the retrial of Knox, 25, for the 2007 murder of British student Meredith Kercher.

The move potentially pits a U.S. constitutional ban on double jeopardy, or being tried twice for the same offense after an acquittal, against international extradition agreements, experts said.

The issue hinges on whether a lower court decision overturning her conviction amounted to an acquittal, they said.

If Knox is retried after she was acquitted, that would violate her constitutional rights, said Christopher Blakesley, a law professor at the University of Nevada Las Vegas who specializes in international criminal law. On the other hand, the United States entered into an extradition treaty and, in doing so, accepted Italy's criminal justice system, he added.

"If Knox is found guilty, there's still a whole lot of room for battle before she would ever be extradited," Blakesley said.

Knox and her former boyfriend, Raffaele Sollecito, were accused of killing 21-year-old Meredith Kercher during a drug-fuelled sexual encounter in Perugia, Italy. The two were found guilty in 2009 and sentenced to 26 and 25 years in prison respectively.

In 2011, an appeals court, comprised of a panel of judges and lay jurors, overturned the convictions of Knox and Sollecito after forensic experts challenged evidence from the original trial. Knox and Sollecito were released after four years in prison, and Knox returned to her family home near Seattle.

Prosecutors and Kercher family lawyers appealed to Italy's high court, the Court of Cassation, calling the prior ruling "contradictory and illogical."

On Tuesday, the Court of Cassation agreed to overturn the appeals court's acquittals. The high court has not yet provided a full reasoning for its decision, and a date has not yet been set for the new trial, which will be held before a different court of appeals in Florence.

Knox's Italian lawyer, Carlo Dalla Vedova, said via email that the new trial would likely occur in late 2013 or early 2014. Knox does not intend to return to Italy for the proceeding, he said, and the court of appeals can retry the case in absentia.

The Italian government could ask for extradition once the Italian courts have reached a final decision, Dalla Vedova said. If it does, the U.S. Department of State would then have to decide whether to act on the request. If the State Department chooses to comply, it would then deploy the U.S. Attorney's Office to a U.S. court to seek Knox's extradition.

What is unpredictable is how such a case would play out in front of a U.S. judge who would have to weigh the U.S. constitutional protection against double jeopardy with the 1984 bilateral extradition treaty between the United States and Italy. The treaty contains a provision that attempts to protect against double jeopardy, but it is not clear whether that provision would bar extradition in Knox's case.

The legal question would be whether Knox was acquitted, as U.S. courts would define the term, or whether the case was merely reversed and still open for further appeal, said criminal lawyer and Harvard Law Professor Alan Dershowitz.

"It's very complicated, and there's no clear answer. It's in the range of unpredictable," Dershowitz said.

Much of the complication stems from the differences between the Italian and U.S. legal systems. In the United States, if a defendant is acquitted, the case cannot be retried.

FILE - In this Sept. 26, 2008 file photo, American murder suspect Amanda Knox , center, is escorted by Italian penitentiary police officers to Perugia's court at the end of a hearing, central Italy. ... more? FILE - In this Sept. 26, 2008 file photo, American murder suspect Amanda Knox , center, is escorted by Italian penitentiary police officers to Perugia's court at the end of a hearing, central Italy. On Wednesday, Nov. 18, 2009 Rudy Hermann Guede, of the Ivory Coast, appealing his conviction for murdering British student Meredith Kercher in Italy, testified Wednesday that he heard the victim arguing with American defendant, Amanda Knox, in the case minutes before she was slain. Guede's appeals process began Wednesday even as the initial trial implicating American student Amanda Knox, of Seattle, and Knox's ex-boyfriend, Raffaele Sollecito, continued. (AP Photo/Pier Paolo Cito, files) less? ?

In Italy, prosecutors and lawyers for interested parties, such as Kercher's family, can file an appeal. Unlike American courts of appeal, which only consider legal errors in the courts below, Italian courts of appeal, which are comprised of both judges and jurors, can reconsider the facts of a case.

Depending on the Italian high court's reason for overturning Knox's acquittal, it is possible that the court of appeals could consider new evidence that's introduced, said Dalla Vedova. As a result, a defendant can effectively be retried in the course of one case in Italy.

Dalla Vedova said the high court's decision does not raise a double jeopardy problem because the retrial would not be a new case but rather a continuation of the same case on appeal.

Other defendants who have been acquitted in other countries and then convicted on appeal have attempted to raise the double jeopardy principle to avoid extradition, without much success, said Mary Fan, a law professor at the University of Washington who specializes in cross-border criminal law.

The text of the treaty prevents extradition if the person has already been convicted or acquitted of the same offense by the "requested" country, which would be the United States in Knox's case because Italy would be requesting extradition from the United States. Because Knox was never prosecuted or acquitted for homicide in the United States, the treaty's double-jeopardy provision would not prevent Knox's extradition, said Fan.

While the issue is rare in the United States, several courts have rejected the double jeopardy argument in similar cases. In 2010, a federal court in California found that a man who was acquitted of murder in Mexico and later convicted after prosecutors appealed the acquittal, could not claim double jeopardy to avoid extradition to Mexico. That court cited a 1974 decision from the 2nd U.S. Circuit Court of Appeals in New York, that reached the same conclusion with respect to Canadian law, which also allows the government to appeal an acquittal.

When asked about the potential extradition of Knox at a press briefing on Tuesday, a spokesman for the U.S. State Department said the question was hypothetical and declined to comment.

(Reporting By Terry Baynes; Editing by Sandra Maler)

Source: http://news.yahoo.com/knox-case-could-pit-extradition-treaty-against-u-002108339.html

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The 2014 Jeep Cherokee looks like a sports car, and not everyone is happy

By Paul Lienert

DETROIT (Reuters) - The 2014 Jeep Cherokee revives one of the brand's hallowed nameplates, one that dates back nearly 40 years. But the Chrysler Group's new crossover vehicle looks like it would fit better in Italian cousin Alfa Romeo's future product stable.

The latest iteration of the Cherokee, the fourth to wear that badge since 1974, makes its public debut this week at the New York International Auto Show and goes on sale at U.S. dealers in late summer.

But the racy design of the 2014 Cherokee has been stirring up a social-media storm, especially among Jeep loyalists, since Chrysler released the first official photos in late February.

"American variant of Nissan Juke, unfortunately . . . No more tough'n'rough," complained one online Jeep forum member.

Responded another: "It is sexy, looks tough and is gonna kick some butt! Thanks, Jeep, for keeping it fresh and relevant."

Chrysler executive Ralph Gilles, who heads the automaker's design department, responded simply to critics on his Twitter feed: "Time will tell."

The decision to resurrect the Cherokee name might not be so controversial if the new crossover didn't represent a radical departure from previous boxy-looking Jeep designs.

The original Cherokee, a full-size two-door companion to the Jeep Wagoneer, was built from 1974 to 1983 by American Motors.

A smaller and even more squarish-looking Cherokee was launched in 1984 by AMC, which was acquired two years later by Chrysler. After the second-generation Cherokee was retired in 2001 by Chrysler, it was replaced by the Liberty, which was sold in overseas markets as the Cherokee before it, too, was phased out last year.

The 2014 Cherokee was designed to broaden the Jeep brand's reach, both in North America and overseas.

In addition to breaking out of the traditional design box, the new Jeep sports a sloping nose whose signature seven-slot grille wraps up and into the hood, and is flanked by stacked headlamps.

It is being built in Ohio, where Chrysler is pouring $1.7 billion into its Toledo plant, parts of which date to 1910 and which once housed Jeep's original owner, Willys-Overland.

The new Cherokee is built on the same mechanical underpinnings as the Dodge Dart and the Alfa Romeo Giulietta. All three use a vehicle architecture originally developed in Italy by Chrysler's corporate parent, Fiat.

The 2014 Cherokee will be the first crossover to use Chrysler's new nine-speed automatic transmission. It will offer buyers a choice of three four-wheel-drive systems and two engines, a 184-horsepower 2.4-liter four cylinder and a 271-horsepower 3.2-liter V6.

Chrysler said the four-cylinder Cherokee is expected to have an EPA highway fuel-economy rating of 31 miles per gallon.

The 2014 Cherokee will come in four versions: Sport, Latitude, Limited and Trail Hawk.

(Reporting By Paul Lienert in Detroit; Editing by Steve Orlofsky)

Source: http://news.yahoo.com/2014-jeep-cherokees-racy-design-stirs-social-media-104238665--finance.html

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Wednesday, March 27, 2013

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Mesothelioma The three Main Types - Professur Gestaltung ...

In general, asbestos is just a unusual kind of cancer. Several types of mesothelioma are distinguished between by where in actuality the cancer is growing. Pleural mesothelioma, the most frequent, accounting for 75% of mesothelioma cases, is where cancerous cells develop on the lining of the lungs. The next most frequent form of mesothelioma is peritoneal mesothelioma and this is where cancerous cells grow on the peritoneum which can be the filling of the stomach. Pericardial mesothelioma, minimal common significant type of mesothelioma, makes up roughly 5% of all mesothelioma cases. That is where malignant cancer cells grow on the liner of one?s heart.

All three of these kinds of mesothelioma are caused by asbestos. Asbestos is a naturally occurring fibrous mineral that was discovered round the 1860s. Due to its extremely of use property of being fireproof, asbestos was used greatly in building in the 1940s, 1930s and 1920s. It had been not until the early 1960s when the severe health hazards that asbestos causes were discovered, that asbestos stopped getting used. When subjected to asbestos with inadequate protection an individual can breathe small asbestos fibers which are suspended in the air. Until they become set in the coating of the lungs these fibers pass in to the breathing. As time passes, a build up of these asbestos fibers in the lungs could cause pleural mesothelioma. Asbestos fibres may also go into the lymphatic system and be transferred to both the coating of the abdomen or the tissue surrounding the heart. This can cause either peritoneal mesothelioma or pericardial mesothelioma.

In terms of symptoms, the three main types of mesothelioma have some symptoms in common together. These signs are typical of most three types: chest suffering, shortness of breath, coughing, coughing up blood, vomiting, sickness, weight loss and loss of appetite. Yet another sign of pericardial asbestos is shivers.

There are a few solutions for many kinds of mesothelioma but none of those have a high success rate. The effectiveness of the treatment depends upon how early and how strongly the cancer is treated. If the malignant cells are treated when they have fully matured and developed then it?s unlikely that treatment options will undoubtedly be effective. Treatment options include chemotherapy which is the use of drugs to kill the cancer, radiation therapy which uses a radiation dosage to kill off malignant cells and surgery which attempts to achieve long term control within the cancer by eliminating a sizable portion of malignant cells. These treatments may be combined in the shape of combined therapy. click

Source: http://www.damm-net.org/blog/2013/03/mesothelioma-the-three-main-types/

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Superhero supercomputer helps battle autism

Mar. 26, 2013 ? When it officially came online at the San Diego Supercomputer Center (SDSC) in early January 2012, Gordon was instantly impressive. In one demonstration, it sustained more than 35 million input/output operations per second--then, a world record.

Input/output operations are an important measure for data intensive computing, indicating the ability of a storage system to quickly communicate between an information processing system, such as a computer, and the outside world. Input/output operations specify how fast a system can retrieve randomly organized data common in large datasets and process it through data mining applications.

The supercomputer's record-breaking feat wasn't a surprise; after all, Gordon is named after a comic strip superhero, Flash Gordon.

Gordon's new and unique architecture employs massive amounts of the type of flash memory common in cell phones and laptops--hence its name. The system is used by scientists whose research requires the mining, searching and/or creating of large databases for immediate or later use, including mapping genomes for applications in personalized medicine and examining computer automation of stock trading by investment firms on Wall Street.

Commissioned by the National Science Foundation (NSF) in 2009 for $20 million, Gordon is part of NSF's Extreme Science and Engineering Discovery Environment, or XSEDE program, a nationwide partnership comprising 16 high-performance computers and high-end visualization and data analysis resources.

"Gordon is a unique machine in NSF's Advanced Cyberinfrastructure/XSEDE portfolio," said Barry Schneider, NSF program director for advanced cyberinfrastructure. "It was designed to handle scientific problems involving the manipulation of very large data. It is differentiated from most other resources we support in having a large solid-state memory, 4 GB per core, and the capability of simulating a very large shared memory system with software."

Last month, a team of researchers from SDSC, the United States and the Institute Pasteur in France reported in the journal Genes, Brain and Behavior that they used Gordon to devise a novel way to describe a time-dependent gene-expression process in the brain that can be used to guide the development of treatments for mental disorders such as autism-spectrum disorders and schizophrenia.

The researchers identified the hierarchical tree of coherent gene groups and transcription-factor networks that determine the patterns of genes expressed during brain development. They found that some "master transcription factors" at the top level of the hierarchy regulated the expression of a significant number of gene groups.

The scientists' findings can be used for selection of transcription factors that could be targeted in the treatment of specific mental disorders.

"We live in the unique time when huge amounts of data related to genes, DNA, RNA, proteins, and other biological objects have been extracted and stored," said lead author Igor Tsigelny, a research scientist with SDSC as well as with UC San Diego's Moores Cancer Center and its Department of Neurosciences.

"I can compare this time to a situation when the iron ore would be extracted from the soil and stored as piles on the ground. All we need is to transform the data to knowledge, as ore to steel. Only the supercomputers and people who know what to do with them will make such a transformation possible," he said.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/computers_math/information_technology/~3/VbpIo_prCLE/130326162343.htm

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